Soufflé Therapeutics Raises $135M Series B to Advance RNA Delivery Platform

Watertown, Massachusetts-based Soufflé Therapeutics is developing RNA medicines that can reach specific cell types beyond the liver, a longstanding challenge for oligonucleotide therapies. Its REMEDY platform uses targeted delivery approaches to direct these treatments into tissues such as muscle and heart.

The company has raised $135 million in an oversubscribed Series B led by Juvia Group. TCG Crossover Management, BB Biotech, Fidelity Management & Research, Balyasny Asset Management, Amgen Ventures and a broad group of existing backers also participated, including ARCH Venture Partners, Bessemer Venture Partners and Temasek.

Soufflé will use the financing to move its first three RNA-delivery programs toward clinical development and continue advancing its pipeline. The programs address facioscapulohumeral muscular dystrophy, heart failure with reduced ejection fraction, and muscle and metabolic disorders.

The lead program has not yet entered clinical testing, making early human data a key upcoming milestone. The company was founded and is led by Victor Kotelianski, Daniel Anderson, Robert Langer, Marino Zerial, Brad Pentelute and Amir Nashat, who will guide development as Soufflé prepares its first program for the clinic.

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